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Crohn's disease may cause sores, or ulcers, that tunnel through the intestine and into the surrounding tissue, often around the anus and rectum. These abnormal tunnels, called fistulas, are a common complication of Crohn's disease. They may get infected. Crohn's disease can also cause anal fissures. Fistulas · Anal fistula. The first sign can be a tender swelling or lump in the area round the anus. · Bladder fistula. Symptoms include passing air, pus, or poo.